5 Most Common Myths & Facts about IVF

In more than 40 years after the first IVF baby was born, advanced reproductive technology has come a long way. IVF is now one of the most successful techniques for those who are having difficulty conceiving a child. IVF has become extremely popular as a result of its success, with an increasing number of couples and individuals searching out all the information they can about the procedure.

Unfortunately, information about IVF might lead to confusion and myths. Some of the myths about IVF are completely false, while others may contain a bit of truth. We at Asha IVF Centre would like to put an end to these myths and misinformation once and for all. We’ll differentiate fact from fiction as we debunk the top five IVF myths.


  1. Ovarian stimulation causes cancer:

Fact: The scientific literature contains numerous well-designed research that has addressed this specific problem. None of them has shown that injectable gonadotropin stimulation promotes cancer in the ovary. There are generally some studies showing a new possible link with borderline ovarian cancers; however, these tumours are indolent (cause little or no pain) and have a good diagnosis (probable prognosis) when it comes to fertility preservation. The American Society for Reproductive Medicine (ASRM) considers it safe for an egg donor to contribute eggs for up to six cycles. It signifies that the regulatory agency in charge of reproductive medicine and assisted reproductive technology (ART) has considered ovarian stimulation to be safe to happen at least six occasions explained at Ashakiran IVF treatment centre in Pune.


  1. IVF has an increased risk of multiple pregnancies(twins, triplets, or more).

Fact: IVF is the only fertility treatment that allows you to choose how many embryos you want to implant. There is currently no control, even with alternative therapies such as oral or injectable medicines, intercourse, or insemination.

For example, all the eggs that have matured during ovarian stimulation with the intrauterine insemination (IUI) cycle have a chance of being fertilised and resulting in a pregnancy. With Clomid, there will be a 10% chance of multiples per cycle, and with injectable gonadotropins, there will be a 25% chance of multiple pregnancies per cycle. 

Elective single embryo transfer (eSET) provides patients with equal success rates when transplanting a single, carefully selected embryo without the possibility of multiple pregnancies would be present if multiple embryos were to be relocated. Elective single embryo transfer (eSET) has emerged as a new, good option for individuals as a result of experience, rigorous analysis of outcomes, and breakthroughs in embryo culturing technologies. Doctor Ashish Kale explained that patients can now have a very healthy singleton pregnancy, which eliminates the complications associated with multiple gestation pregnancies.


  1. IVF Misconception: It is only for those who are wealthy.

Fact: IVF is costly, yet it is less expensive than a number of other procedures. Its price has not increased in the last few years.


  1. IVF Misconception: It is only for young partners.

Fact:  While the age does play a vital role in fertility, the results are always better if you opt for this treatment at a younger age but yes this definitely is an option for elderly patients who may have faced problems in the past like decreasing ovarian reserves. Donor eggs from young girls are used in the elder age groups. However, it is important to remember that maternity rates in older women are lower than in younger women.


  1. IVF Misconception: IVF babies are born with birth abnormalities and malformations.

Fact: The risk of having an IVF child with abnormalities is quite low. In natural or IVF kids, the risk of an abnormal fetus is the same as in the general population.


A Step-By-Step Look at the IVF Process

When you think about typical fertility treatments, in vitro fertilization (IVF) is definitely at the top of everyone’s list. There’s a good explanation for it.A STEP-BY-STEP LOOK AT THE IVF PROCESS

IVF has been around for a long time, and you’re probably familiar with the basic concept: combining egg and sperm outside the body in culture. But there’s a lot more to IVF than that, both before and after the procedure. Here’s a five-step breakdown of the IVF procedure.

IVF is widely used to treat the following conditions:

Fertility problems in older women

Women who have fallopian tubes that are damaged or occluded

Endometriosis affects women of all ages.

  • Infertility in men induced by a low sperm count or sperm blockage


IVF Process in Five Easy Steps

  1. Superovulation can help you increase your egg output: (Day 2 – 10)

Fertility medicines will be administered to you, which will start a process known as egg stimulation or superovulation. To put it another way, the medications, which contain Follicle Stimulating Hormone, will instruct your body to generate more than one egg per month.

The more eggs you create, the better your chances of fertilization later in the process.

During this stage of the IVF process, you’ll have regular transvaginal ultrasounds and blood tests to check your ovaries and monitor your hormone levels.


HCG Trigger: (Day 12)

Human chorionic gonadotropin (hCG), a hormone that causes follicles to break and release an egg, is the real trigger injection.

Gonadotropic hormones like FSH and LH stimulate the ovaries for egg growth to achieve pregnancy during an ovarian stimulation cycle.

  1. Remove the eggs (Day 14 & 15)

At this stage, the eggs will then be removed using a small surgical procedure known as follicular aspiration. It’s usually done as an outpatient procedure in your doctor’s clinic.

Your doctor will use an ultrasound to guide a small needle into each of your ovaries through your vagina during the surgery. The needle is equipped with a mechanism that suctions the eggs out one by one.


  1. Collect sperm from your partner or a donor (Day 14 – 15)

While your eggs are being removed, your partner will provide a sperm sample. You also may choose to use donor sperm. The sperm are then put through a high-speed wash and spin cycle to find the healthiest ones.


  1. Unite sperm and eggs (Day 16 – 18)

Now comes the most well-known phase of IVF: pairing your best sperm with your best eggs. Insemination is the term for this stage.

A sperm normally takes a few hours to fertilize an egg. Instead of injecting the sperm directly into the egg, we at Ashakiran Hospital opt for intracytoplasmic sperm injection (ICSI) if needed or sperms are less.


  1. Transfer the embryo(s) into your uterus (Day 18 – 20)

You’ll receive yet another medication after your eggs have been collected. This one is for preparing the uterine lining to receive the embryos transferred back into you.

Your doctor will implant the embryos into your uterus using a catheter three to five days after fertilization. This part of IVF is done while you are awake at your doctor’s clinic, like the third phase.

Multiple embryos are transferred back into you, hoping that at least one will implant itself in the lining of your uterus and begin to develop.

Multiple embryos can implant at the same time, which is why multiples are prevalent in IVF patients.

The IVF process resembles natural reproduction. The next stage after the IVF process determines if the procedure worked—the pregnancy test.


Effect of Vitamin B2 Deficiency on Pregnancy

Vitamin B2 that is riboflavin, is a constituent of flavoenzymes concerned with energy metabolism and antioxidant function. 

A recommended amount of vitamin B2 for pregnant women is 1.4 mg every day. 

Vitamin B2 deficiency has been connected to preeclampsia.

Even though the exact cause of preeclampsia is not recognised, reduced intracellular levels of B2 could result in mitochondrial dysfunction — increase the oxidative stress and get in the way of nitric oxide release and consequently blood vessel dilation —leading to preeclampsia. 

Effect of Vitamin B2 deficiency during pregnancy:

If you’re pregnant, it’s extremely crucial to have enough riboflavin in your diet. A riboflavin deficit could jeopardise your baby’s growth and raise your risk of preeclampsia, a dangerously high blood pressure condition that occurs during pregnancy. It is a dangerous condition that can life-threatening.

Getting enough vitamin B2

Eat a healthy and balanced diet to get enough vitamin B-2. It’s present at the levels most people need in dairy products, including cottage cheese and milk.

Other sources include:

  • egg yolks
  • red meat
  • dark meat
  • salmon
  • tuna
  • soybeans
  • almonds
  • grains, such as wheat

But don’t forget to consult your doctor before consuming any naturally high vitamin B2 or any supplement. 


7 Tips For Taking Care Of Yourself After Embryo Transfer

7 TIPS FOR TAKING CARE OF YOURSELF AFTER EMBRYO TRANSFERThe day of transfer is an exciting part of the IVF process. It’s game day, and everything you’ve done in the weeks leading up to getting ready for the embryo transfer. You’ve taken your meds as prescribed, followed your doctor’s advice and lived a balanced lifestyle. You and your embryo are both ready.

Remember that you and your fitness are the top priority right now and for the next few weeks. Though treating yourself like the glass isn’t appropriate (the embryo won’t fall out!), you can relax and take it easy. 

Follow these following tips to make sure you’re taking care of yourself right after the embryo transfer.

On the day of your embryo transfer, your fertility team will go through detailed post-transfer guidelines for you. Spend the next few days pampering yourself. Gentle motions are best, no hard exercise, lifting, twisting, or turning. Here are a few more ways to look after yourself after your embryo transfer:

  1. Relax: The embryo will implant in the next few days, so you must relax and think positive. If at all necessary, take a few days off work. Unplug from the rest of the world’s concerns. You’ll be able to return to daily news, social media, and all of life’s other obligations in due time. A post-transfer walk through the park or beach with your partner is in order. Enjoy your favourite nutritious meal while binge-watching your favourite comedy TV show or the new romantic comedy you’ve been wanting to see.
  2. Continue Taking Your Medicines: Make sure you take your medicines and injections if any as prescribed.
  3. Embrace Healthy Eating: You’ve been following a healthy eating plan in preparation for IVF, and you can keep doing so. After all, if everything goes according to plan, you’ll be carrying a baby in one month and you’ll want to be in great shape. You can take a stroll or walk, continue your office work and eat all kinds of food.
  4. Folic Acid Is a Must: If you haven’t already started taking a folic acid supplement, now is a good time to do so. Supplementing with folic acid has been shown to reduce the risk of neural tube defects, heart defects, and cleft palate. Consult your doctor to determine how much folic acid you need.
  5. Limit Your Exposure to Endocrine Disrupting Chemicals: Of course, you’re cautious about your exposure to something that might endanger your pregnancy or unborn child. Many daily objects contain endocrine-disrupting chemicals. Particularly at this time, try to restrict your exposure to these things (it’s virtually impossible to avoid them entirely).
  6. Don’t Ignore Disturbing Symptoms: Now is the time to pay careful attention to your body and, if anything seems “wrong,” call your doctor right away. It’s most probably nothing, but worrying and stressing over things is never a positive thing.
  7. Avoid the Temptation to Take a Pregnancy Test: You may be tempted to take a pregnancy test. Please do not do so. It will take a few weeks for your body to produce enough HCG, the pregnancy hormone, to confirm your pregnancy. When the “what ifs” start to creep in, it’s time to take action.


The next few weeks will be long, but you will get there, just as you did on transfer day. Waiting for the results of your pregnancy test.

After your embryo transfer, taking care of yourself is a great way to start incorporating healthy habits into your life. And, if it hasn’t already, making your wellbeing a top priority is long overdue.

Dr. Ashish KaleIVF Specialist in Pune at Ashakiran Hospital is highly known for providing the best embryo transfer treatment.


High-Risk Pregnancy- Here’s How You Can Manage It

High-Risk Pregnancy- Here’s How You Can Manage It

Although for most people, pregnancy should be a normal and risk-free experience, some women may experience a high-risk pregnancy. If there are possible risks that could prove dangerous for the infant, mothers, or both, in such cases the pregnancy is considered high-risk.

Health conditions such as high blood pressure, diabetes, autoimmune disorders, lung/kidney/heart defects, or any other complications during pregnancy or childbirth, lead many people to such a pregnancy.


There are a few steps you can take to avoid a high-risk pregnancy, as well as a few tips for dealing with one. Continue reading to learn more about them:


  • Pre-conception Consultation:

Before pregnancy, you should make a few moves. A preconception consultation will help your health care professional in assisting you in achieving a healthy weight before becoming pregnant, prescribing vital supplements, adjusting medications, and discussing the dangers you may face as a result of your health conditions. This could lower the chances of having a high-risk pregnancy in the future.


  • Regular visits to the health care provider

Prenatal care is essential to keep track of your wellbeing and the growth of your infant. If the condition warrants, you will be referred to a professional, and all questions or concerns will be answered. The quicker a problem is identified, the greater the chances of successfully managing it.


  • Eat a well-balanced diet:

This may seem self-evident, but you’ll need to supplement your body with folic acid, calcium, protein, and iron when pregnant. To support your baby’s wellbeing, you’ll need to gain weight as well. This also means you’ll have to stay away from things like alcohol and tobacco.


  • Anxiety management:

Anxiety can be harmful to both the mother and the child’s wellbeing. You should speak with your health care professional and ask for suggestions about how to relax and stay calm in the face of adversity. A few interventions, such as recommended exercise or music, can aid in the reduction of undue stress.


  • Tests:

An ultrasound, chorionic villus sampling, cordocentesis, ultrasound for cervical duration lab studies, and a biophysical profile may be requested by your doctor to monitor the baby’s growth and handle the risks appropriately.

Some prenatal diagnostic tests, such as amniocentesis and chorionic villus screening, carry a slight risk of pregnancy loss, so the mother and her husband must decide whether or not to get them performed after consulting with their health care provider.


  • Signs of Risk:

Vaginal bleeding, discomfort or cramping in the lower abdomen, extreme headaches, contractions, reduced foetal function, pain or burning during urination, water vaginal discharge, and vision changes should all be kept in mind. Do not overlook this and refer to a good hospital like Ashakiran Hospital and doctor like Dr. Ashish Kale immediately.


Male Infertility Evaluation & Treatment


Male Infertile can have more than one cause, so it’s likely you will both need to see a gynaecologist. It might take a few tests to determine the cause of infertility. 

  1. Semen Analysis:

This is a routine lab test in which semen is collected in a sterile tube, and the sample is studied. The quality of the sperm is analyzed by studying sperm volume, sperm count, movement, concentration, and structure. Reports are given on the same day.

  1. Hormone Evaluation:

Testosterone and other hormones are responsible for the production of healthy sperms. Hormone evaluation also helps the doctor to rule out if you are suffering from any other underlying health problem.

  1. Testicular Biopsy:

This test is done when your semen analysis shows low sperm count or no sperms. A needle biopsy is taken to check for the presence of healthy sperms. This helps to diagnose if there is any blockage, and also these sperms can be used in the process of assisted reproduction.

  1. Surgical Sperm Retrieval (SSR)Techniques :
  1. Percutaneous Epididymal Sperm Aspiration (PESA):

A small needle is placed into the epididymis, which is a reservoir of sperm that sits atop each testicle, using local/general anaesthesia and sperms are aspirated.

2. Testicular Sperm Aspiration (TESA) /Testicular Sperm Extraction (TESE):

If PESA is unsuccessful, TESA or TESE may be offered. In this procedure, the sperm is obtained directly from the testicle either by a needle or a tissue biopsy.

3. MicroTESE:

MicroTESE is done under the microscope where our urologist dissects out only microscopic tissue (tubule) from areas with dilated seminiferous tubule, identified as having active spermatogenesis. Sperm may be found in 50-60% of well-selected cases. Microscopic tissue removal ensures no harm is done to the testis.

Treatment Protocol

  1. Lifestyle Changes:

We ensure that the male partner loses weight, takes a good diet rich in antioxidants, exercises regularly and reduces stress. At the same time, he quits smoking alcohol and any other addictions.

  1. Hormone Replacement:

If hormones are deficient and are required to boost sperm production we start the replacement therapy (hCG & FSH). This therapy takes at least 3 months to show results.

  1. Surgical Interventions:

In case of dilated veins in the testis surgical clipping (Variocelectomy) is done. This brings down the raised local temperature of testis enhancing sperm production. In case the outlet duct (vas deferens) is blocked and the condition is good enough to try and repair. 


We at Ashakiran – Infertility Center in Pune, ensure that we identify the cause of infertility and address it accordingly. Dr. Ashish Kale an IVF Specialist, provides excellent Female and Male Infertility treatment in Pune to his patients. 



male infertility in pune

Nearly 1 in 7 couples is infertile, which means they haven’t been able to conceive a child even though they’ve had frequent, unprotected sexual intercourse for a year or longer. In up to half of these couples, male infertility plays at least a partial role.

Male infertility is on the rise and now accounts for nearly 40% of causes, It is seen that poor semen parameters may be due to some illness or fever or due to local infections, stress, pollution and bad diet. It could also be that there is the failure of the testis to produce sperm due to trauma or infections in the testis. which can be caused by low sperm production, abnormal sperm function or blockages that prevent the delivery of sperm. Chronic health problems, lifestyle choices and other factors may contribute to male infertility.

The inability to conceive a child can be stressful and frustrating, but several treatments are available for male infertility. 

Evaluation includes-

  1. Semen analysis to check the number, movement and shape of the sperm in the ejaculation
  2. Blood tests may also be done to check the hormone levels that control sperm production.
  3. Genetic investigations to test for chromosomal anomalies or Y chromosome microdeletion may be done.

Male Infertility can be a reason for stress amongst couple but there are various treatments available for it. Dr. Ashish Kale is an IVF Specialist having Infertility Center in Pune.   

Common Myths Associated with Male Infertility

7 Most Common Myths Associated with Male Infertility

Indian society mostly saddles women with the responsibility of bearing children, which signifies it’s the female who is blamed for being infertile should there be a delay or absence in pregnancy. Today, we’re debunking such myths by presenting a must-know list of myths and facts about male infertility. Like – did you have any idea that being overweight could harm the quality of sperms and overall sperm production? Here’s Dr. Ashish Kale, who provides special treatment for  Male Infertility in Pune, lays forward the causes behind it. He says, “Male infertility can often be treated, but first it’s necessary to clear the taboos and certain myths and seek medical help.” 

  1. Myth:

The biggest myth surrounding infertility is that infertility could be a female problem. 

Fact: “This isn’t true. In fact, in about 40% of cases of infertility; the issue lies with the male. We do see numerous cases where thousands of tests for females are done but not a single semen analysis is done for the male partner.”

  1. Myth: Stress is one of the main causes of infertility. 

Fact: “False. Stress affects one’s drive but not the semen quality or quantity and thus won’t result in infertility. So, if the sexual relations are ok and a lady still doesn’t conceive, then medical help should be sought for both the partners.”

  1. Myth: Keeping the testicles cold will enhance semen quality. 

Fact: “False. Cooling testicles with ice isn’t only dangerous but ineffective too. However, wearing tight undergarments, and prolonged driving should be avoided because it raises the scrotal temperature and affects sperm quality. Also, heat and radiation from the prolonged use of a laptop on the lap and frequent use of hot tubs or saunas aren’t good for sperms and is proven by many studies to decrease the sperm count.”

  1. Myth: Only older men have infertility problems. 

Fact: “No, even young men can have severe infertility problems. Absence of sperms or very low sperm counts is often encountered at ages as young as 20.”

  1. Myth: Does smoking and drinking cause infertility in men? 

Fact: “Agreed. Quitting smoking and drinking alcohol moderately is helpful as both are known to make sperm toxic.”

  1. Myth: Nutritional supplements don’t help in enhancing sperm quality. 

Fact: “Anti-oxidants like vitamin C, Vitamin E, zinc, selenium do help up to some extent.”

  1. Myth: Mobile phones kept within the pocket radiate electromagnetic waves, which damage sperm quality. 

Fact: “Well, this can be not always true as these concerns are yet to be proven by larger studies.”

Dr. Ashish Kale – IVF Specialist in Pune is also the founder of Ashakiran Hospital – A Infertility Center in Pune. He continuously shares his knowledge with his clients and creating awareness in the society about various topics.

Causes & Symptoms of Hypothyroidism

Causes & Symptoms of Hypothyroidism

The thyroid is a small, butterfly-shaped gland that drapes across the front of your windpipe.

If you place your fingers on the sides of your Adam’s apple and swallow, you’ll feel your thyroid gland sliding under your fingers.

It releases thyroid hormone, which controls the growth and metabolism of essentially every part of your body.

The pituitary, a tiny gland in the middle of your head, monitors your physiology and releases thyroid-stimulating hormone (TSH). TSH is the signal to the thyroid gland to release thyroid hormone.

Sometimes TSH levels increase, but the thyroid gland can’t release more thyroid hormone in response. This is known as primary hypothyroidism, as the problem begins at the level of the thyroid gland.

Other times, TSH levels decrease, and the thyroid never receives the signal to increase thyroid hormone levels. It is called secondary hypothyroidism.

Hypothyroidism, or “low thyroid,” can cause a variety of signs and symptoms. This article will help you recognize and understand these effects.


  1. Weight Gain:

Unexpected weight gain is another common symptom of hypothyroidism.

Not only are low-thyroid individuals moving less — they’re also signaling their livers, muscles and fat tissue to hold on to calories.

When thyroid levels are low, metabolism switches modes. Instead of burning calories for growth and activity, the amount of energy you use at rest, or your basal metabolic rate, decreases. As a result, your body tends to store more calories from the diet as fat.

Hypothyroidism signals the body to eat more, store calories and burn fewer calories. This combination leads to weight gain.


  1. Fatigue:

One of the most common symptoms of hypothyroidism is feeling worn out. Thyroid hormone controls energy balance and can influence whether you feel ready to go or ready to nap. Those with high levels of thyroid hormone feel nervous and jittery. In contrast, people with low thyroid feel exhausted and sluggish.

In one study, 138 adults with hypothyroidism experienced physical exhaustion and reduced activity. They also reported low motivation and feeling mentally tired



  1. Hair Loss:

Like most cells, hair follicles are regulated by thyroid hormone.

Because hair follicles have stem cells that have a short lifespan and rapid turnover, they are more sensitive to low thyroid levels than other tissues.

Low thyroid hormone causes hair follicles to stop regenerating, resulting in hair loss. This will typically improve when the thyroid issue is treated.



  1. Menstrual Irregularities:

Both irregular and heavy menstrual bleeding is linked to hypothyroidism.

One study showed that about 40% of women with low thyroid hormone experienced increasing menstrual irregularity or heavy bleeding in the last year, compared to 26% of women with normal thyroid levels


  1. Constipation:

Low thyroid levels put the brakes on your colon.

According to one study, constipation affects 17% of people with low thyroid hormone, compared to 10% of people with normal thyroid levels

While constipation is a common complaint in patients with hypothyroidism, it’s uncommon for constipation to be the only or most severe symptom.


  1. Changes in Skin Texture:

Like hair follicles, skin cells are characterized by rapid turnover. Therefore, they are also sensitive to losing growth signals from the thyroid hormone.

When the normal cycle of skin renewal is broken, the skin may take longer to regrow.

This means the outer layer of skin has been around longer, accumulating damage. It also means that dead skin may take longer to shed, leading to flaky, dry skin.



  1. Diabetes:

Hyperthyroidism is typically associated with worsening glycemic control and increased insulin requirements. There is underlying increased hepatic gluconeogenesis, rapid gastrointestinal glucose absorption, and probably increased insulin resistance. Indeed, thyrotoxicosis may unmask latent diabetes.


  1. Depression:

Hypothyroidism is linked to depression. The reasons for this are unclear, but it might be a mental symptom of an overall decrease in energy and health.

64% of women and 57% of men with hypothyroidism report feelings of depression. About the same percentage of men and women also experience anxiety


  1. Infertility:

Low levels of thyroid hormone can interfere with the release of an egg from your ovary (ovulation), which impairs fertility. In addition, some of the underlying causes of hypothyroidism — such as certain autoimmune or pituitary disorders — may impair fertility.


The thyroid is a crucial gland in our body and considering these various factors that it can have an impact on Dr. Ashish Kale – An IVF Specialist in Pune recommends not only his patients but others as well to not ignore these symptoms and have a close watch on it and take the necessary precautions. 





1st IVF Baby in Arunachal Pradesh

In vitro fertilization commonly known as IVF Treatment is a complex procedure consisting of various steps. IVF Treatment is usually used to helps people with fertility or prevents genetic problems and also assists with the entire process of conception of a child. In IVF treatment, mature eggs are retrieved from women’s ovaries and are fertilized by male sperm in a clinical lab. Once the eggs are fertilized they are transferred back into the uterus. 


Dr. Ashish Kale is the founder of Ashakiran Hospital Pune and is a know IVF Specialist in Pune. He has immensely contributed in the field of IUI/IVF treatment as well as an infertility treatment for male infertility and female infertility. 


“Arunachal IVF” centre in collaboration with Dr. Ashish Kale’s – Asha IVF Centre is the First IVF centre to start in the state of Arunachal Pradesh with the opening of Late Dr. Nirmali Taba block on 21 December 2019. With IVF specialists Dr. Jomson Bagra, Dr. Ashish Kale and Dr. Ashwini Kale as senior embryologist the team worked extremely hard to set up an IVF centre in the state of Arunachal Pradesh. 


Within a few days of the established, a couple interested in IVF treatment opted for it. Following a Frozen Embryo transfer on 21st February 2020, the patient was successfully able to conceive a pregnancy which continued smoothly. A planned elective C-section was fixed on the 25th of October. But due to unavoidable circumstances, the baby was successfully delivered on 19th October 2020. A special day for the state of Arunachal Pradesh when a First IVF baby was born from our own Niba Hospital. An angel is born, both the mother and baby are doing well. 

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