Are blastocyst transfers more successful?

The blastocyst transfer has given couples the opportunity to have healthier children with fewer birth defects and abnormalities. The use of blastocysts has resulted in a significant increase in the success rate of IVF treatment, according to researchers.

Blastocyst transfer is the most commonly used technique in IVF treatment. The cost of the procedure is usually included in the cost of the IVF treatment.

List of factors limiting the number of embryos that survive the Blastocyst transfer stage;

First, the embryo’s inherent health informs us about its ability to grow and divide. Some eggs may begin to fertilize, but only a few make it to the four-cell stage on the second day in culture. On the third day in culture, some still reach the eight-cell stage, and even fewer develop into a blastocyst. In layman’s terms, only the healthiest embryos will survive.

The culture media was the second factor that limited the growth of embryos in culture. Researchers identified the shortcomings of the in vitro culture environment and created new culture solutions, such as blastocyst media. These are high in life-sustaining nutrients, giving the embryos the best chance of developing naturally.

As a result, embryos are exposed to specific media designed to meet the nutritional needs of each stage of development beginning with egg collection.

Third, even embryos with the potential for good growth and better culture media require additional factors. Some of them include the knowledge and skill of the laboratory embryologists who handle this important work, which is critical to achieving good blastocyst development. As a result, it is critical to select the best laboratory that has obtained the most opportunities for patients in their IVF cycles to assist in the building of a family.

Benefits of Blastocyst Transfer

The use of embryo culture in IVF allows for the identification of embryos with the highest development efficiency. It also aids in maintaining embryonic age at the same time as endometrial, allowing for early communication between the two. This technique necessitates the use of more than one medium to meet the metabolic needs of the developing embryo.

Other advantages include:

  1. Blastocyst transfer is more physiological because the human embryo goes through several transformations. This occurs during the first four days of life, as the embryo grows and separates from a fertilized oocyte to the Blastocyst stage. It demonstrates changes in nutrient requirements and utilization, which aids in the formation of stage-specific culture media. It aids in the development of the embryo during the preimplantation period.
  2. The implantation rate in Blastocyst transfer is higher because the embryos have more time to develop in the laboratory. This makes it easier for the embryologist to select the embryo that will be implanted in the womb. According to the study, the success rate of blastocyst transfer based on clinical pregnancy rate is 43.4 per cent per blastocyst transfer.
  3. During the blastocyst transfer, a small number of embryos are transferred to the uterus. This reduces the likelihood of multiple pregnancies and increases the likelihood of success. As a result, only one or two embryos are implanted in the uterus. When two embryos are transferred, it results in multiple pregnancies in 25% of such cases because both embryos begin to develop.
  4. Preimplantation Genetic Diagnosis (PGD) is easier to perform on a blastocyst because more cells can be used for production and testing. PGD tests to aid in the elimination of faulty embryos and ensure that a good embryo free of genetic defects is transferred during the IVF procedure.

Blastocyst Transfer recommended for to whom?

IVF Specialist in Pune at Ashakiran Hospital will recommend Blastocyst Transfer to the couples who have repeatedly failed to conceive after transferring high-quality cleaved embryos (if the embryos are implanted and do not respond to a blastocyst, it may indicate a potential egg problem).

And also to those who want to become pregnant without the risk of having multiple pregnancies.

 And Couples who do not want their extra embryos frozen.

If you looking for Infertility Center in Pune for Blastocyst Transfer you can visit Ashakiran Hospital.


Decoding Male Infertilty

Decoding Male Infertility

Most couples patiently await the event of starting a family. Unfortunately, many couples struggle with infertility, which can negatively influence the experience. When a couple is having difficulty getting pregnant, the common societal misconception is that the woman is having difficulties. This is not true; in fact, studies show that male factor infertility accounts for approximately 40% of all infertility cases!

What Causes Male Infertility?

Male infertility can be caused by hormonal imbalances, illness, infection, reproductive anatomy injury, obstruction, or sexual dysfunction. These factors can have a temporary or permanent effect on sperm, preventing conception. The longer some disorders go untreated, the more difficult they are to treat. That is why it is critical to first establish a definitive diagnosis of what is causing your infertility.

How to deal with Infertility?

At Ashakiran Hospital, our goal is to help you realize your wish of having a child.  With extensive experience in the field of infertility, we treated many patients for both male and female infertility. Ashakiran Hospital also provides Male Infertility treatment in Pune.

We recommend that both partners be tested for infertility and that any obstacles that prevent you from becoming parents be addressed. And, if male factor infertility is the cause, you can be confident that our IVF specialists in Pune will find you the most effective treatment option.

Male infertility is typically caused by one of two factors: a deformity in the reproductive system caused by injury, infection, or disease, or problems with the sperm produced. In this section, we have defined briefly the various physical conditions that can affect male fertility.

Disorders of the Sperm

A sperm defect causes approximately 25% of all infertility, and a sperm defect is the main cause or a contributing cause in 40-50% of infertility cases. We also know that men with very low sperm counts can have children, whereas men with healthy sperm counts do not always. This indicates that the ability of sperm to fertilize an egg is more important than the number of sperm.

Defects and disorders of the sperm are usually on a molecular level – the sperm can be irregularly shaped, motile, or low in number, all of which can prevent the eggs from fertilizing.

Dr Ashish Kale works as an Infertility Specialist at Ashakiran IVF Centre to determine the cause of your infertility and plan treatment for you and your partner to achieve a successful pregnancy.


What Causes Erectile Dysfunction

Erectile dysfunction, or ED, is a prevalent sexual problem among males. Is it a common occurrence in India? According to research every year, around 10 million males in India are diagnosed with it. Fortunately, this is a curable problem.

What is erectile dysfunction?

Some men are unable to achieve or maintain an erection long enough to engage in sexual activity. Not getting an erection at times of stress or grief is quite natural. However, Erectile Dysfunction is a condition in which the problem becomes chronic, meaning that getting an erection is constantly difficult.

Because Erectile Dysfunction makes a guy believe he is impotent, it can have a traumatic effect on his mind.

How will you know if you have Erectile Dysfunction for sure?

If you have Erectile Dysfunction, you will experience the following symptoms:

  • Low libido
  • Ejaculation that occurs too soon
  • Incapacity to experience orgasm

If these symptoms last longer than two months, you are most certainly suffering from erectile dysfunction.


Why should you be concerned about erectile dysfunction?

Erectile dysfunction can be a sign of an underlying health condition as well as a source of marital problems. One of these disorders that need rapid care can cause ED.

  • Problems with the heart
  • Blood vessels that are clogged
  • LDL hypertension is characterized by high levels of bad cholesterol (LDL).
  • Diabetes
  • Parkinson’s disease is a neurological disorder that affects people.
  • Sleep disturbances

What factors increase your chances of developing Erectile Dysfunction?

Here are a few things that increase your chances of developing erectile dysfunction:

  • Tobacco smoking narrows your blood vessels and decreases the blood supply to your penis (an erection is only possible when a large volume of blood travels to the penis).
  • Obesity also affects the flow of blood to the penis.
  • Surgery or radiation therapy for prostate cancer.
  • An injury to the nerves or arteries that supply blood to the penis.
  • A procedure that involves the spinal cord or nerves.
  • Drinking excessively or abusing drugs.

Is Erectile Dysfunction curable?

Fortunately, erectile dysfunction can be controlled. Speaking with a therapist can assist you in overcoming the mental barriers that hinder you from achieving an erection.

If some medications you’re taking are the cause of your problem, your doctor may lower the dose or change the prescription. You can visit to Ashakiran hospital as they provide Male Infertility treatment in Pune.

Infertility center in Pune

What is Ejaculation Disorder, and how does it affect you?

Ejaculatory dysfunction occurs when a man is unable to ejaculate effectively. It’s the most common type of male sexual dysfunction, and it’s frequently the root of infertility in men.

Disorders of the ejaculatory system are not uncommon. Premature ejaculation (PE) affects roughly 30-40% of men at some point in their lives. Premature Ejaculation is also reported by one in every five men aged 18 to 59, according to research.

Premature, delayed, retrograde, and ejaculatory dysfunction are the four forms of ejaculatory dysfunction. These disorders have various effects on ejaculation and can lead to sexual dissatisfaction.

  1. Premature Ejaculation

When a male ejaculates before or shortly after penetration, this is known as premature ejaculation (PE). Before orgasm, most men have ejaculation

Various reasons might cause premature ejaculation, including:

  • Hormone concentrations
  • Sensitivity of the sperm
  • Sexual arousal is low
  • Anxiety about performing

Premature Ejaculation can be treated in a variety of ways. Premature Ejaculation, like most sexual health issues, is treated differently depending on the reason. PE can be treated with physical therapy, psychotherapy, and medicines. The idea is to reduce penile sensitivity while improving a man’s capacity to manage his behavioural responses.

  1. Delayed Ejaculation (DE)

When a guy ejaculates after sexual stimulation, this is known as delayed ejaculation (DE).

DE happens from time to time, but it might become a concern if it happens frequently.

Delay in ejaculation can be caused by a variety of factors, including drugs, heavy alcohol use, diuretics, high blood pressure, and sexual performance anxiety. Hormonal abnormalities and low self-esteem can also contribute to DE.

  1. Retrograde ejaculation (RE)

When some or all of the ejaculate moves backwards, it is referred to as retrograde ejaculation (RE) (retrograde). Instead of coming out of the penis during the climax, the ejaculate returns to the bladder. It eventually passes via the kidneys during urination.

This ejaculation condition might lead to infertility if left unchecked. A malfunctioning bladder neck muscle is the most common cause of RE. The muscles can also dysfunctional due to prostate or bladder surgery.

Medical diseases, such as diabetes or a spinal cord injury, as well as some drugs, can cause this harm. Prostate or bladder surgery can potentially cause muscular dysfunction.


  1. Anejaculation

Men who suffer from anejaculation usually take an exceptionally long time to ejaculate, while some never do. Anejaculation is a condition in which some men are unable to orgasm or ejaculate, while others can orgasm but not ejaculate. Men can also ejaculate without orgasm due to anejaculation.

Several causes can contribute to this ejaculatory dysfunction, including:

  • Hormonal imbalances
  • Aging
  • Semen ducts clogged
  • Problems with the mind
  • Prescription drugs (SSRIs)
  • Diseases of the nervous system
  • Certain surgical procedures, including prostate and testicular cancer surgery, can also cause an ejaculation.

If you’re having issues with erectile dysfunction, premature ejaculation or other sexual dysfunction, visit to Infertility center – Ashakiran Hospital and schedule an appointment to have a consultation with an experienced and one of the best IVF Specialist in Pune, Dr Ashish Kale.

IVF Specialist

What Effect Does PCOS Have on Fertility?

PCOS, or Polycystic Ovary Syndrome, is a hormonal disorder that affects 10% of reproductive-age women. The fact that 70% of PCOS cases go undetected due to a lack of understanding about the disorder is frightening. PCOS tends to interfere with your life in ways you may not be aware of. But do not be disappointed! Let’s clear up some frequent PCOS inquiries so you may put your fears to rest.

What causes PCOS to occur? What are the impacts on Women?
While there is no definitive answer as to what causes PCOS, there has been some research that links certain characteristics to the condition. Genes are one of them. Some research has discovered a relationship between PCOS and heredity. Another issue that contributes to PCOS is insulin resistance. Insulin resistance causes the body to produce too much insulin, which leads the ovaries to release more male hormones. Diabetes and PCOS are both increased as a result of this. PCOS can harm a woman’s body, which is why it’s so important to get it diagnosed. Low metabolism, obesity, sleep apnea, endometrial cancer, and depression are just a few of the side effects. However, one of the most often asked questions by women around the world is, “Does PCOS Affect a Woman’s Ability to Conceive?” Yes, PCOS stops the egg from being released regularly, which makes fertilizations difficult. PCOS has a high prevalence of infertility, with about 75% of women with the condition having difficulty conceiving.

How PCOS treatment does happen?
Birth control pills to manage the cycle, Metformin to regulate insulin, Clomiphene to promote fertility, and, in some situations, surgery is some of the most frequent approaches to treat PCOS. It is crucial to remember, however, that these drugs can have adverse effects, which is why it is best to consult a doctor before deciding on the best treatment option for you. Dr Ashish Kale is the IVF Specialist in Pune. Following a nutritious diet and maintaining a regular exercise regimen are two things you may do at home to help with PCOS therapy. Obesity continues to be the leading cause of PCOS infertility, thus it’s critical to address it first. PCOS sufferers can improve their fertility by losing just 5-10% of their body weight.

Why choose Ashakiran Hospital for PCOS and infertility Treatment?
Ashakiran Hospital is a well-known Infertility Center in Pune that has a high success rate with IVF in PCOS patients. Fertility treatments can be difficult for the body to handle and can sometimes go wrong. Overstimulation of the ovaries to create more eggs during IVF in PCOS individuals might have hazardous consequences for the body. Ashakiran Hospital is aware of these dangers and employs strategies to mitigate them. Instead of being stimulated for 4-5 weeks, the ovaries are stimulated for only 10-11 days. This prevents the ovaries from being overstimulated or hyperstimulated.
PCOS and infertility might be difficult to deal with, but it is possible to conceive even if you have PCOS. Ashakiran Hospital is led by Dr Ashish Kale, who is an expert in IVF treatments. To schedule an appointment, please contact us on


Male Infertility Evaluation & Treatment

Male Infertile can have more than one cause, so it’s likely you will both need to see a gynaecologist. It might take a few tests to determine the cause of infertility. 

  1. Semen Analysis:

This is a routine lab test in which semen is collected in a sterile tube, and the sample is studied. The quality of the sperm is analyzed by studying sperm volume, sperm count, movement, concentration, and structure. Reports are given on the same day.

  1. Hormone Evaluation:

Testosterone and other hormones are responsible for the production of healthy sperms. Hormone evaluation also helps the doctor to rule out if you are suffering from any other underlying health problem.

  1. Testicular Biopsy:

This test is done when your semen analysis shows low sperm count or no sperms. A needle biopsy is taken to check for the presence of healthy sperms. This helps to diagnose if there is any blockage, and also these sperms can be used in the process of assisted reproduction.

  1. Surgical Sperm Retrieval (SSR)Techniques :
  1. Percutaneous Epididymal Sperm Aspiration (PESA):

A small needle is placed into the epididymis, which is a reservoir of sperm that sits atop each testicle, using local/general anaesthesia and sperms are aspirated.

2. Testicular Sperm Aspiration (TESA) /Testicular Sperm Extraction (TESE):

If PESA is unsuccessful, TESA or TESE may be offered. In this procedure, the sperm is obtained directly from the testicle either by a needle or a tissue biopsy.

3. MicroTESE:

MicroTESE is done under the microscope where our urologist dissects out only microscopic tissue (tubule) from areas with dilated seminiferous tubule, identified as having active spermatogenesis. Sperm may be found in 50-60% of well-selected cases. Microscopic tissue removal ensures no harm is done to the testis.

Treatment Protocol

  1. Lifestyle Changes:

We ensure that the male partner loses weight, takes a good diet rich in antioxidants, exercises regularly and reduces stress. At the same time, he quits smoking alcohol and any other addictions.

  1. Hormone Replacement:

If hormones are deficient and are required to boost sperm production we start the replacement therapy (hCG & FSH). This therapy takes at least 3 months to show results.

  1. Surgical Interventions:

In case of dilated veins in the testis surgical clipping (Variocelectomy) is done. This brings down the raised local temperature of testis enhancing sperm production. In case the outlet duct (vas deferens) is blocked and the condition is good enough to try and repair. 


We at Ashakiran – Infertility Center in Pune, ensure that we identify the cause of infertility and address it accordingly. Dr. Ashish Kale an IVF Specialist, provides excellent Female and Male Infertility treatment in Pune to his patients. 



male infertility in pune

Nearly 1 in 7 couples is infertile, which means they haven’t been able to conceive a child even though they’ve had frequent, unprotected sexual intercourse for a year or longer. In up to half of these couples, male infertility plays at least a partial role.

Male infertility is on the rise and now accounts for nearly 40% of causes, It is seen that poor semen parameters may be due to some illness or fever or due to local infections, stress, pollution and bad diet. It could also be that there is the failure of the testis to produce sperm due to trauma or infections in the testis. which can be caused by low sperm production, abnormal sperm function or blockages that prevent the delivery of sperm. Chronic health problems, lifestyle choices and other factors may contribute to male infertility.

The inability to conceive a child can be stressful and frustrating, but several treatments are available for male infertility. 

Evaluation includes-

  1. Semen analysis to check the number, movement and shape of the sperm in the ejaculation
  2. Blood tests may also be done to check the hormone levels that control sperm production.
  3. Genetic investigations to test for chromosomal anomalies or Y chromosome microdeletion may be done.

Male Infertility can be a reason for stress amongst couple but there are various treatments available for it. Dr. Ashish Kale is an IVF Specialist having Infertility Center in Pune.   

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