The process of preparing the uterus for a frozen embryo transfer

Couples frequently use frozen embryos to increase their chances of becoming pregnant after a single IVF or ICSI round. When using frozen embryos, the embryos must first be thawed before being transferred to the uterus. A uterus can be prepared in three ways for the transfer of a thawed frozen embryo.


  1. Menstrual cycle in its natural state

The embryo can be transferred naturally if you ovulate frequently. We must monitor the growth of your eggs, the thickness of your endometrial lining (uterine lining), and your hormone levels to determine when the embryo should be transferred.

We can track the growth of your eggs and assess the thickness of your endometrial lining with a vaginal ultrasound. A blood test is required to determine hormone levels. Your embryo can be transferred if the follicle size, endometrial thickness, and hormone levels are all normal.

After the right amount of days, your embryo is placed in the uterus (six days later if a blastocyst is to be transferred or four days later if a day 3 embryo is to be transferred). There is a chance of natural pregnancy if you have intercourse during the cycle, in addition to the likelihood of embryo transfer success.


  1. Ovulation induction with FSH

FSH ovulation induction is a good option if you’re not ovulating regularly and have enough eggs in your ovary to ovulate.

FSH is a hormone injection that promotes the development of many eggs. Because of the danger of multiple pregnancies, you may be asked to refrain from sexual activity if two or more eggs mature in the ovary. If natural conception is possible, there is a possibility of twinning, just as there is with natural cycle FET. Injections of human chorionic gonadotropin (HCG) can trigger ovulation.


  1. The replacement of the hormones cycle.

If you’re not ovulating regularly, have a low quantity of good eggs, or are experiencing endometrial thickening, a hormone replacement cycle may be the best option for you.

To prevent egg formation from the ovary interfering with hormone levels, which impact the endometrial lining, a GnRH agonist (General) is often administered. Every three days, a table or patch is put to the skin to help thicken the endometrial lining. A second hormone, progesterone, is given vaginally once the endometrial lining has reached the desired thickness (Utrogestan, Endometrin or Crinone).

After the progesterone is started, the embryo is transferred to the uterus at the right moment. Pregnancy screenings are required via blood tests, and if the test is positive, hormones must be continued until the foetus is about eight or nine weeks old, at which point the placenta generates enough hormones to keep the pregnancy in place. After 10 weeks of pregnancy, the hormone dosages are gradually discontinued.

Frozen Embryo Transfer

Frozen embryo transfer (FET) Process

Frozen embryo transfer (FET) is a lifesaver for couples who are unable to proceed with a fresh embryo transfer due to medical reasons or who want to try again in the future.

According to research, frozen embryo transfers account for roughly half of all embryo transfers performed in assisted reproductive institutions.

What are Frozen Embryo Transfer and How Does It Work?

Embryos that were generated during previous IVF cycles and were kept for later use are known as frozen embryos.

How are embryos frozen?

The resulting embryo is allowed to develop for a few days after the egg and sperm are fertilized in the laboratory.

Because not every embryo can tolerate the freezing process, an embryologist picks the embryos that are suitable for freezing. After that, the embryo is placed in a solution that protects it from freezing damage. The embryo is frozen using a cutting-edge process that involves rapidly cooling it to sub-zero temperatures.

Until the couple agrees to use the embryo, it is preserved in liquid nitrogen.


When is it advisable to use frozen embryo transfer?

If you’re having trouble conceiving, your doctor may consider freezing embryos for later use.

  • Have a fibroid or polyp in the uterine cavity that may interfere with implantation are sick at the time of egg retrieval
  • Are at risk of having ovarian hyperstimulation syndrome because they have not yet built a strong uterine lining for fresh transfer (OHSS)
  • Fresh transfers have resulted in failure cycles
  • Are employing surrogates or donated embryos, or have extra good quality embryos to use in future attempts


What is the procedure for transferring frozen embryos?

Following the retrieval of your eggs and collection of your sperm, the best quality sperm will be chosen and fertilized with the egg under controlled settings in an IVF laboratory.

As Dr Ashish Kale explains the frozen embryo transfer step by step, “the resulting embryos are allowed to grow for 3-5 days.” The embryo will then be frozen until you are ready to use it.

Delaying the transfer gives the woman’s body time to recover from the drugs or injections she received during IVF. This helps to establish a stress-free environment that is more favourable to implantation.


What is the success rate of frozen embryo transfer?

Pregnancy success rates for deferred embryo transfer have been shown to be comparable to those for natural conception.


Did you know that endometriosis can be treated

10% of women of reproductive age suffer from Endometriosis.

Endometriosis is nothing but the presence of active endometrium outside the uterine cavity it may lead to painful periods, decrease egg reserve and problems in getting pregnant.

Endometriosis can cause severe pain, particularly during menstrual periods. Fertility issues may also arise. Effective treatments are, fortunately, available.

But when diagnosed at the right time and treated correctly, you can bear a child.There’s a misconception that it can lead to cancer- no it cannot it’s treatable.It’s time women talk about it and get the correct treatment. So please visit the IVF Specialist in Pune at Ashakiran Hospital.

Endometriosis has no known cure.

Surgery or medication are generally used as treatments. You may need to try a variety of treatments to figure out what works best for you.

Pain relievers – Over-the-counter pain treatment may be recommended by IVF Specialist.
Many patients benefit from non-steroidal anti-inflammatory medicines (NSAIDs), such as ibuprofen (Advil, Motrin) or naproxen (Aleve). If these don’t help, talk to your specialist about additional possibilities.



Fibroids impact on Fertility

What exactly are fibroids?

Uterine fibroids are masses of muscle tissue in the uterus that are benign (noncancerous). Myomas and leiomyomas are other names for them. Fibroids originate when a single muscle cell in the uterine wall multiplies and matures into a benign tumour.

Fibroids can alter the form and size of the uterus, as well as the cervix in some cases (lower part of the uterus). Although most women have several fibroid tumours, solitary fibroids are conceivable. Fibroids’ location, size, and number determine whether they produce symptoms or require treatment. Fibroids are most commonly found in or around the uterus’s body, however, they can also be found in the cervix.

Fibroids are classified into three categories based on where they are found:

Subserosal refers to the uterus’s outer wall (55 percent)

Intramural are present in the uterine wall’s muscular layers (40 percent) Protrusion of the submucosa into the uterine cavity (5 percent)

Fibroids can also have a stalk (pedunculated) that connects them to the uterus, or they might be related to adjacent ligaments or organs like the bladder and colon. Outside of the pelvic cavity, fibroids are uncommon.

How frequent are they?

Fibroids affect 20% of reproductive-age women; however, they are more common in African-American women (50 percent -80 percent). Although the specific cause of uterine fibroids is unknown, research suggests that it is caused by a mix of genetic, hormonal, and environmental factors.

Can They Affect Fertility?

Fibroids affect about 5% to 10% of infertile women. Fibroids’ size and location influence whether or not they have an impact on fertility. Fibroids that are inside the uterine cavity (submucosal) or fibroids that are very large (>6 cm in diameter) within the uterine wall are examples (intramural). The majority of fibroids-affected women are not infertile. Before fibroids are treated, women with fibroids and their partners should be thoroughly screened to rule out any fertility issues. An IVF Specialist can help determine whether fibroids are interfering with conception.

Uterine fibroids can affect fertility in several ways:

The number of sperm that can enter the uterus might be affected by changes in the shape of the cervix. The migration of the sperm or embryo can be hampered by changes in the shape of the uterus. Fibroids can obstruct the fallopian tubes. They affect the size of the uterine cavity lining. The uterine cavity’s blood flow may be hampered. An embryo’s ability to stick (implant) to the uterine wall or develop may be harmed as a result of this.

Fibroids and pregnancy: what happens?

Fibroids are found in 2% to 12% of pregnant women, however not all fibroids grow larger or cause complications during pregnancy. A fibroid is most likely to grow during the first 12 weeks of pregnancy.

What can happen if you have fibroids while pregnant?

The main concern during pregnancy is whether the fibroid would raise the risk of preterm labour or miscarriage. Fibroids can overrun their blood supply and produce significant pain in some circumstances. You may need to be admitted to the hospital. Fibroids can also cause the baby’s position in the uterus to alter. Miscarriage, preterm delivery, and caesarean section are all risks associated with this.

Your doctor’s suggestions and your scenario will determine how you treat your fibroids. During pregnancy, surgery is rarely required or performed.

If a woman becomes pregnant after having a fibroid removed, she should talk to the obstetrician who will deliver the baby. It’s possible that a caesarean section will be advised.


Uterine fibroids are prevalent and can have a variety of effects on fertility. They can influence whether sperm and egg meet, whether an embryo implants, whether a pregnancy continues and the baby’s growth and location. Treatment is determined on an individual basis. It is based on fibroids’ symptoms and may help with overall fertility. The intensity of your symptoms and IVF Specialist suggestions will determine how and whether you treat your fibroids.

female fertility

Impact of Age on Female Fertility

While age may not be a barrier to achieving many of your goals, it can be the single most difficult obstacle to overcome when it comes to conceiving. Normally, we would not ask a lady her age, but it will be the first question asked at a fertility clinic because a woman’s age is one of the most crucial factors determining her capacity to conceive.

The age of a woman is a crucial determinant of her fertility. Women’s fertility peaks in their early and mid-twenties then begin to decline progressively after that. After the age of 36, one’s ability to conceive decreases drastically. After 36 years, the chances of conceiving naturally drop to half of what they were at 20 years, and these changes continue to fall even drastically after the age of 40.

After the late 30s, the number of healthy eggs produced by women begins to decline, lowering the odds of conception. With increasing age, the quality and quantity of eggs decrease, resulting in a decline in infertility. Here are a few elements that are directly linked to growing older and have an impact on women’s fertility:


Fertilization Failures: The embryo needs the energy to grow and divide, and this energy is provided by the egg in the form of little packets known as mitochondria. With growing age, the number of mitochondria in eggs decreases, resulting in less energy available for fertilization, resulting in an unsuccessful effort to conceive.


Ovarian Reserve: As women become older, their ovarian reserve shrinks. In general, a woman’s reserve is estimated to be 12 per cent at the age of 30, decreasing to 3 per cent at the age of 40.

Miscarriages are more likely at an older age because chromosomal abnormalities in the eggs are more common, which can lead to defective embryos, which can lead to implantation failure and raise the odds of miscarriage.


Unexplained Infertility: Women of a certain age have a larger probability of being diagnosed with unexplained infertility than women of a younger age.


Age is something that no one can control; it will continue to rise, resulting in a decrease in reproductive capacity. As a result, it’s better to have a baby when you’re in your prime reproductive years. Assisted reproduction, on the other hand, can increase your chances of conceiving and having a child.


Get the best female infertility treatment with the highest success rates at Ashakiran Hospital. Get a proper consultation with the IVF Specialist in Pune, Dr Ashish Kale.

endometriosis and its treatments

Endometriosis and its Treatments

What is Endometriosis?

Endometriosis is a condition in which tissue that looks like the lining of your uterus develops outside of it. The endometrium is the uterine lining.

Endometriosis is a condition in which endometrial-like tissue forms on the ovaries, intestines, and pelvic tissues. Endometrial tissue rarely spreads beyond the pelvic region, but it can happen. An endometrial implant is an endometrial tissue that has grown outside of your uterus.

The displaced endometrial tissue is affected by the hormonal fluctuations of your menstrual cycle, causing it to become irritated and uncomfortable this means the tissue will thicken, grow, and eventually break down. The damaged tissue finally gets stuck in your pelvis because it has nowhere else to go.

This trapped tissue in your pelvis might cause the following problems:

  • Scarring and adhesions are a source of discomfort (tissue that ties your vaginal organs together)
  • Fertility difficulties and intense discomfort during periods

Endometriosis symptoms

Endometriosis can present in several ways. Some women experience only minor symptoms, while others experience symptoms that range from mild to severe. The severity or stage of your condition has nothing to do with the degree of your pain. You could be in agonizing agony even if you have a mild instance of the illness. It’s also possible to have a severe kind while only feeling minor discomfort.

What causes Endometriosis?

During a regular menstrual cycle, the lining of your uterus is lost. This allows menstrual blood to travel from your uterus to your vaginal canal through the tiny opening in the cervix.

Endometriosis has no recognized cause, although there are several speculations about what causes it, none of which have been scientifically proven.

According to one of the early theories, endometriosis is caused by a process known as retrograde menstruation. This occurs when menstrual blood returns to your pelvic cavity via your fallopian tubes rather than escaping through the vagina.

According to another theory, hormones drive cells outside the uterus to transform into endometrial cells, which line the lining of the uterus.

Others feel that if endometrial tissue grows in small abdomen areas, the sickness will develop. This could be because the cells in your abdomen are embryonic cells that can change shape and function like endometrial cells. It’s not clear why this happens.

Endometrial cells may have shifted to the surfaces of your pelvic organs, including your bladder, ovaries, and rectum. They continue to form, thicken, and bleed during your menstrual period in reaction to the hormones in your cycle.


Endometriosis Treatment Options

There are two types of treatment for Endometriosis.

One is a medical treatment that involves taking tablets and also includes hormonal treatment,

The other one is Surgical Treatment, where you have to go under Surgery.

You have to visit your fertility consultant to decide what kind of treatment you will need because the treatment options depend on the age of patients, kind of symptoms, type of endometriosis and desire for fertility or to have a child.

Immunity boosting tips during your pregnancy

Immunity boosting tips during your pregnancy

During pregnancy, a woman’s body must respond to several changes. This is why a pregnant woman demands extra attention and comfort. During pregnancy, a woman’s immunity serves as a protective barrier against disease, germs, bacteria, toxins, and infections. Immunity, as the name implies, works as an immunological device in our digestive system to combat a variety of fitness issues. According to the research, a woman’s immune system is compromised during pregnancy.

The following are some tips to assist women to boost their immunity when pregnant.

1) Take probiotics on a daily basis.

Probiotics are commonly present in dairy products such as milk and yoghurt. Probiotics, on the other hand, must be ingested in the form of supplements. The ingestion of probiotics boosts the immunity of both the pregnant mother and the youngster. Prevent your child from developing comparable allergies, bronchial allergies, and many fitness issues.

2) Eat a well-balanced and nutritious diet.

It is critical to follow a healthy and nutritious diet throughout your pregnancy. A well-balanced food plan may enable you to begin without trouble and without major issues. Pregnant women’s approaches are aided by a nutritious eating routine, which includes:

– In addition to strengthening the immune system, this healthy eating plan enhances the body’s energy level.

– Always keep in mind that you should eat enough food to sustain two lives when pregnant.

3) Get enough rest and live in a stress-free environment

During pregnancy, women want more relaxation and comfort than they do during other times of their lives. In this regard, you should rest completely and try to sleep for at least eight hours in the afternoon, avoiding the use of cell phones for an extended period of time. Because a mobile Smartphone impairs a toddler’s cerebral health, use it only when absolutely required.

4) Eat a vitamin C and vitamin D-rich diet

Vitamin C and D are essential for developing immunity. In most cases, a pregnant woman’s doctor will prescribe diet C on a regular basis. Include those nutrients in your diet, and you’ll be able to:

– Boost immunity by eating lemons, oranges, citrus fruits, and strawberries, for example.

– Eat a diet high in Vitamin D to boost your immunity. – These nutrients also help with fertility.

5) Work on your physical fitness

Pregnant women might enhance their immunity levels by sticking to a strict workout programme. Physical activity improves blood flow throughout the body, allowing you to avoid a variety of fitness issues.

6) Never hesitate to drink water; drink as much as you can

For pregnant women, drinking plenty of water is essential. Water is essential for keeping your body hydrated and active. Water should be seen as the most important requirement for pregnant women. Water assists in keeping the body hydrated and active.

However, if you are experiencing a severe problem, you should visit an Ashakiran Hospital for more treatment.


How to Manage Low Ovarian Reserve?

What is ovarian reserve?
Any IVF stimulation programme aims to produce a large number of good-quality eggs and a healthy uterine environment. It refers to the ease with which an individual’s ovaries can be successfully simulated using fertility medicines in a practical sense. The woman’s age is the single most consistent factor impacting ovarian reserve.
A low ovarian reserve is defined as a lack of quantity and quality of eggs at a given age. Women with a poor ovarian reserve have a difficult time getting pregnant, and in some cases, conception may be difficult. The menstrual cycle can be irregular, with heavy and light periods, as well as being late or short. Miscarriage can also be caused by a low ovarian reserve. Despite the fact that there are treatments for this condition-
Low ovarian reserve is caused by a variety of factors, including:
• Age
• Smoking
• Excess intake of alcohol
• Endometriosis
• Tubal diseases
• Chemotherapy
• Radiation therapy
• Infections inside the pelvic area
• Autoimmune disorders
• Genetic abnormalities
• Mumps
Despite the fact that poor ovarian reserve can make it difficult to conceive, early diagnosis and treatment can help to improve the chances. We can assess ovarian reserve by having specialists certify it in order to determine the ovary’s function and quality.
The IVF Specialists can recommend IVF Treatment or any other treatment for infertility based on the circumstances and the ovarian exam.
The experts at First Step IVF are certified to do ovarian reserve examinations for infertile couples and those who are seeking a pregnancy. If you are identified with a poor ovarian reserve, you will be given the appropriate treatment and consultations from Ashakiran Hospital.


Top Natural Painkillers

Individuals have utilized fundamental oils, spices, and elective treatments as normal pain killers for many years.

Analysts have not completely investigated these choices; however, some proof recommends that specific cures can help and that many individuals think that they are valuable.

In this article, we examine some regular pain killers and the science behind them.

  1. Turmeric

Turmeric is additionally a typical natural solution for decreasing aggravation. To recollect turmeric for its ordinary design in the eating schedule, have a go at adding it to curries, smoothies, or juices. Fresh or dried turmeric is likely to be safe when pregnant women consume it in small amounts, e.g., the amounts typically found in meals, such as curries and other dishes.

  1. Ginger

Ginger is a root that shows guarantee as a characteristic pain killer.

A 2015 efficient review trusted Source found that ingesting 2 grams of ginger each day unobtrusively decreased muscle pain from obstruction exercise and running when individuals took it for something like 5 days. Ginger is commonly used to ease morning sickness during pregnancy, and studies have shown it’s safe and effective for this purpose. Talk to IVF Specialists about using ginger for morning sickness.

  1. Cloves

Individuals have generally utilized cloves, from the Eugenia caryophyllata plant, as a home solution for ease torment from toothache.

A 2006 study trusted Source observed clove gel to be just about as compelling as benzocaine gel, which is an effective gel that dental specialists regularly use to diminish needle torment.

  1. Capsaicin

Individuals additionally use capsaicin, present in bean stew peppers, for normal help with discomfort. This substance can create a gentle consuming or shivering uproar when an individual applies it topically.

Turmeric is additionally a typical natural solution for decreasing aggravation. To recollect turmeric for its ordinary design in the eating schedule, have a go at adding it to curries, smoothies, or juices.

  1. Lavender fundamental oil

Lavender fundamental oil might assist with alleviating torment normally. People use lavender oil to alleviate the inconvenience, help rest, and ease anxiety.

A limited scale 2012 examination found that breathing in lavender oil might assuage torment related to headache migraines contrasted and fake treatment.

  1. Rosemary fundamental oil

Rosemary is fundamental oil that might calm torment.

A few specialists express that Confided in Source the rosemary plant, Rosmarinus officinalis L. may assist with treating migraine, muscle and bone torment, and seizures. Rosemary may likewise diminish aggravation, loosen up smooth muscles, and lift memory.

  1. Peppermint fundamental oil

Some examination recommends that the peppermint plant has mitigating, antimicrobial, and torment assuaging impacts. The dynamic mixtures in peppermint oil incorporate carvacrol, menthol, and limonene.

  1. Eucalyptus fundamental oil

The last fundamental oil on this rundown of regular approaches to mitigate torment is eucalyptus oil. This homegrown cure from the Eucalyptus plant might assist with decreasing torment, expansion, and aggravation in the body.

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